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SET and H2BC1
Data Source:
BioGRID
(pull down)
SET
H2BC1
Description
SET nuclear proto-oncogene
H2B clustered histone 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Chromosome, Telomeric Region
Nucleosome
Nucleus
Nucleoplasm
Extrinsic Component Of Plasma Membrane
Molecular Function
DNA Binding
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Regulator Activity
Histone Binding
Molecular_function
DNA Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Viral Process
Negative Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Histone Acetylation
Regulation Of MRNA Stability
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Nucleosome Assembly
Nucleosome Disassembly
Inflammatory Response
Protein Ubiquitination
Plasminogen Activation
Spermatogenesis, Exchange Of Chromosomal Proteins
Positive Regulation Of Binding
Mononuclear Cell Migration
Pathways
Condensation of Prophase Chromosomes
HuR (ELAVL1) binds and stabilizes mRNA
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Axial length (
24144296
)
Body mass index (
26426971
)
Eating disorders (purging via substances) (
23568457
)
Interacting Genes
68 interacting genes:
ANP32A
APEX1
APP
CALM1
CDCA8
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
ENO1
EP300
ESR1
FAM111B
FBXO7
FOS
FOXO1
GZMA
GZMK
H1-1
H2BC1
H3-3A
H3-4
H4-16
H4C14
HMGB2
IRF1
JUNB
KLF5
KMT2A
LGMN
MDM2
MEOX2
MTERF1
NME1
NUCB1
NUPR1
PAX6
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTEN
PTMA
RAC1
REPIN1
SDCBP
SETBP1
SGO1
SGO2
TAF1A
TERF1
TERF2
TERF2IP
TEX35
THAP7
TLE5
TREX1
TRIM55
TRIM63
UCHL5
XRCC6
ZNF17
ZNF438
ZNF85
8 interacting genes:
ANP32B
APP
CCNA1
DNTTIP2
H2AC20
HDAC3
SET
USP44
Entrez ID
6418
255626
HPRD ID
09023
11024
Ensembl ID
ENSG00000119335
ENSG00000146047
Uniprot IDs
A0A024R895
A0A0C4DFV9
Q01105
Q5VXV3
Q96A08
PDB IDs
2E50
3WKJ
5GSU
5GT3
6BIY
Enriched GO Terms of Interacting Partners
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