PRDM16 and PLK4

Data Source:
BioGRID (two hybrid)

		PRDM16	PLK4
Description		PR/SET domain 16	polo like kinase 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		PKMTs methylate histone lysines	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS		Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		22 interacting genes: ACOT8 ARRB1 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA	22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		63976	10733
HPRD ID		16122	10387
Ensembl ID		ENSG00000142611	ENSG00000142731
Uniprot IDs		Q9HAZ2	O00444
PDB IDs		2N1I 6BW4	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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