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PLK4 and CYLD
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
PLK4
CYLD
Description
polo like kinase 4
CYLD lysine 63 deubiquitinase
Image
GO Annotations
Cellular Component
Spindle Pole
XY Body
Nucleus
Nucleolus
Cytoplasm
Centrosome
Centriole
Cytosol
Cleavage Furrow
Deuterosome
Centrosome
Spindle
Cytosol
Cytoplasmic Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Ciliary Tip
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Zinc Ion Binding
Protein Kinase Binding
Lys63-specific Deubiquitinase Activity
Proline-rich Region Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Centriole Replication
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cytokinesis
Positive Regulation Of Centriole Replication
Trophoblast Giant Cell Differentiation
Ciliary Basal Body-plasma Membrane Docking
De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Negative Regulation Of JNK Cascade
Regulation Of Inflammatory Response
Regulation Of Necroptotic Process
Necroptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Microtubule Cytoskeleton Organization
Protein K63-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of NIK/NF-kappaB Signaling
Regulation Of Cilium Assembly
Negative Regulation Of P38MAPK Cascade
Protein Linear Deubiquitination
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Fostamatinib
Diseases
Familial cylindromatosis
Multiple familial trichoepithelioma
Brooke-Spiegler syndrome
GWAS
Adventurousness (
30643258
)
Asthma (childhood onset) (
31036433
)
Asthma (time to onset) (
27130862
)
Body mass index (
28892062
)
Crohn's disease (
28067908
22412388
)
Femoral neck bone mineral density (
29499414
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
28067908
)
Leprosy (
25642632
22019778
)
Lumbar spine bone mineral density (
29499414
22504420
)
Interacting Genes
22 interacting genes:
ARR3
BTRC
C1orf109
CHD3
CYLD
DNAJB13
ELOA
GAS8
MTUS2
OSBPL3
PRDM16
SFN
SMAD4
SPAG5
TAX1BP3
TEC
TENT5B
TENT5C
TFIP11
TGFBR1
TRIM54
ZBTB39
23 interacting genes:
AKT1
AURKB
DDX58
DLG4
HDAC6
IKBKE
IKBKG
ITCH
MAP3K7
MAPRE1
PLK4
PTPA
TBK1
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM47
TUBA1A
UBC
UBE2D2
UBE2S
Entrez ID
10733
1540
HPRD ID
10387
05427
Ensembl ID
ENSG00000142731
ENSG00000083799
Uniprot IDs
O00444
A0A024R6T1
Q9NQC7
PDB IDs
2N19
3COK
4JXF
4N7V
4N7Z
4N9J
4YUR
4YYP
5LHY
5LHZ
6N45
6N46
6W38
6W3I
6W3J
1IXD
1WHL
1WHM
2VHF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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