PRDM16 and CCDC13

Data Source:
BioGRID (two hybrid)

		PRDM16	CCDC13
Description		PR/SET domain 16	coiled-coil domain containing 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Transcription Repressor Complex	Nucleoplasm Centrosome Cytosol Centriolar Satellite Cell Projection
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Respiration Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Histone H3-K9 Methylation Heterochromatin Organization Positive Regulation Of Cold-induced Thermogenesis	Cellular Response To DNA Damage Stimulus Cytoplasmic Microtubule Organization Non-motile Cilium Assembly
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hypertension ( 31879980) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 23793025 21666692 27322543) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Motion sickness ( 25628336) Nicotine dependence symptom count ( 25555482) Nose morphology ( 29921221) Optic disc size ( 31809533) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) QRS duration ( 25035420) Red blood cell count ( 32888494 27863252) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27618448) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Clozapine-induced agranulocytosis ( 25187353) Obesity-related traits ( 23251661) Periodontitis (DPAL) ( 24024966)
Interacting Genes		22 interacting genes: ACOT8 ARRB1 CCDC13 CFAP206 DDX6 GLMN LENG8 LONRF1 MID2 MIPOL1 NEK6 PATJ PLK4 POLR3C RBBP4 RIOK2 RUNX1T1 TCHP TEX10 TSG101 TXLNA XPA	49 interacting genes: ASB15 CARD9 CCDC120 CCDC136 CCHCR1 CCND3 CDR2 DISC1 EFHC2 EHHADH ENKD1 FAM161A FAM161B FAM221B FAM90A1 FCHO1 GMCL1 GOLGA2 HAP1 HOMEZ HSF2BP KIAA1328 KRT34 LZTS1 MCRS1 MEOX2 MYF5 NEFL OPTN PIBF1 PRDM16 RALBP1 RPSA TCHP TCL1A TFIP11 TP53BP2 TRAF3 TRIM23 TSGA10IP TXLNB USP54 VPS52 ZBED1 ZBTB22 ZBTB43 ZGPAT ZNF670 ZRANB1
Entrez ID		63976	152206
HPRD ID		16122	08692
Ensembl ID		ENSG00000142611	ENSG00000244607
Uniprot IDs		Q9HAZ2	Q8IYE1 Q96LI1
PDB IDs		2N1I 6BW4
Enriched GO Terms of Interacting Partners?
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