PLK4 and TENT5C

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLK4	TENT5C
Description		polo like kinase 4	terminal nucleotidyltransferase 5C
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GO Annotations	Cellular Component	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	RNA Binding Protein Binding RNA Adenylyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	In Utero Embryonic Development Viral Process MRNA Stabilization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39	7 interacting genes: AP2B1 DAZAP2 MVP PLK4 PRKN RHOXF2 TRIP6
Entrez ID		10733	54855
HPRD ID		10387	13312
Ensembl ID		ENSG00000142731	ENSG00000183508
Uniprot IDs		O00444	Q5VWP2
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J	6W36 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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