PLK4 and DNAJB13

Data Source:
BioGRID (two hybrid)

		PLK4	DNAJB13
Description		polo like kinase 4	DnaJ heat shock protein family (Hsp40) member B13
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Cytosol Axoneme Motile Cilium Sperm Flagellum Sperm Connecting Piece
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Chaperone Cofactor-dependent Protein Refolding Axonemal Central Apparatus Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Fostamatinib
Diseases
GWAS			Dimensional psychopathology (Cognitive) ( 29496196)
Interacting Genes		22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39	12 interacting genes: GORASP2 LHX4 MDFI MSS51 PIBF1 PICK1 PLK4 RAB3IP SEPTIN1 TOM1L1 ZC3H12A ZRANB1
Entrez ID		10733	374407
HPRD ID		10387	15573
Ensembl ID		ENSG00000142731	ENSG00000187726
Uniprot IDs		O00444	P59910
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J
Enriched GO Terms of Interacting Partners?
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