PLK4 and TAX1BP3

Data Source:
BioGRID (two hybrid)

		PLK4	TAX1BP3
Description		polo like kinase 4	Tax1 binding protein 3
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GO Annotations	Cellular Component	Spindle Pole XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Fibrillar Center Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cytokinesis Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Activation Of GTPase Activity Negative Regulation Of Protein Localization To Cell Surface
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		22 interacting genes: ARR3 BTRC C1orf109 CHD3 CYLD DNAJB13 ELOA GAS8 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39	13 interacting genes: ARNT2 CDK5RAP3 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29
Entrez ID		10733	30851
HPRD ID		10387	18160
Ensembl ID		ENSG00000142731	ENSG00000213977
Uniprot IDs		O00444	A0A087X282 O14907
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J	2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B 4NNL 4NNM
Enriched GO Terms of Interacting Partners?
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