CTNND1 and FER

Data Source:
HPRD (in vivo)

		CTNND1	FER
Description		catenin delta 1	FER tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Catenin Complex Lamellipodium Growth Cone Midbody Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Chromatin Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Microtubule Cytoskeleton Lamellipodium Cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding
	Biological Process	Cell-cell Junction Assembly Brain Development Wnt Signaling Pathway Adherens Junction Organization Entry Of Bacterium Into Host Cell Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Response To Lipopolysaccharide Cellular Response To Insulin Stimulus Negative Regulation Of Mast Cell Activation Involved In Immune Response Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-6-mediated Signaling Pathway
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells	Signaling by SCF-KIT
Drugs			Fostamatinib
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)	Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 20881960 25282103) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBIN FER GRIK2 GSK3B JUP KCTD6 LCK MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RPS6KA3 SMURF1 SNCA SRC SUMO2 YWHAG ZBTB33	19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB
Entrez ID		1500	2241
HPRD ID		03026	01491
Ensembl ID		ENSG00000198561	ENSG00000151422
Uniprot IDs		O60716	P16591 Q6PEJ9 W0S0X4 W0S1B5
PDB IDs		3L6X 3L6Y	2KK6 6KC4
Enriched GO Terms of Interacting Partners?
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