RIT1 and RALGDS

Data Source:
HPRD (two hybrid)

		RIT1	RALGDS
Description		Ras like without CAAX 1	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Signalling to p38 via RIT and RIN	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		6016	5900
HPRD ID		10195	03371
Ensembl ID		ENSG00000143622	ENSG00000160271
Uniprot IDs		Q92963	Q12967 Q8N4Y1
PDB IDs		4KLZ	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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