GRK1 and PDE6D

Data Source:
HPRD (in vitro, two hybrid)

		GRK1	PDE6D
Description		G protein-coupled receptor kinase 1	phosphodiesterase 6D
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GO Annotations	Cellular Component	Photoreceptor Disc Membrane	Cytoplasm Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Protein Autophosphorylation	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
GWAS			Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		9 interacting genes: ADRB2 CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		6011	5147
HPRD ID		01585	04056
Ensembl ID		ENSG00000185974	ENSG00000156973
Uniprot IDs		Q15835	B8ZZK5 O43924 Q6IB24
PDB IDs		5AFP	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW
Enriched GO Terms of Interacting Partners?
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