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PDE6D and PTGIR
Data Source:
HPRD
(in vivo)
PDE6D
PTGIR
Description
phosphodiesterase 6D
prostaglandin I2 receptor
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Cilium
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
GTPase Inhibitor Activity
Protein Binding
Small GTPase Binding
Guanyl-nucleotide Exchange Factor Activity
Prostacyclin Receptor Activity
Biological Process
Visual Perception
Negative Regulation Of GTPase Activity
Response To Stimulus
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Response To Lipopolysaccharide
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Catalytic Activity
Pathways
ARL13B-mediated ciliary trafficking of INPP5E
RAS processing
Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Treprostinil
Iloprost
Dinoprost tromethamine
Epoprostenol
Beraprost
Selexipag
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Crohn's disease (
28067908
)
Interacting Genes
25 interacting genes:
ARL15
ARL16
ARL2
ARL3
CDC42
CETN3
FAM219A
GNAI1
GRK1
GRK7
HRAS
OTP
PTGIR
RAB13
RAB18
RAB8A
RAD23A
RAP1A
RAP2B
RASA1
RHEB
RHOA
RHOB
RND1
RPGR
10 interacting genes:
ADCY10
GNA11
GNAQ
GNAS
LNX1
PDE6D
PDZD3
PRKCA
RAB11A
TBXA2R
Entrez ID
5147
5739
HPRD ID
04056
08959
Ensembl ID
ENSG00000156973
ENSG00000160013
Uniprot IDs
B8ZZK5
O43924
Q6IB24
P43119
PDB IDs
1KSG
1KSH
1KSJ
3T5G
3T5I
4JHP
4JV6
4JV8
4JVB
4JVF
5E80
5E8F
5F2U
5ML2
5ML3
5ML4
5ML6
5ML8
5NAL
5TAR
5TB5
5X72
5X73
5X74
5YAV
5YAW
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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