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PDE6D and RHOB
Data Source:
HPRD
(in vivo, two hybrid)
PDE6D
RHOB
Description
phosphodiesterase 6D
ras homolog family member B
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Cilium
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Nucleus
Early Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cell Cortex
Endosome Membrane
Cytoplasmic Vesicle
Late Endosome Membrane
Cleavage Furrow
Cell Projection
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
GTPase Inhibitor Activity
Protein Binding
Small GTPase Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Kinase Binding
Biological Process
Visual Perception
Negative Regulation Of GTPase Activity
Response To Stimulus
Mitotic Cytokinesis
Angiogenesis
Intracellular Protein Transport
Apoptotic Process
Actin Filament Organization
Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Endosome To Lysosome Transport
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Cell Migration
Cell Differentiation
Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Regulation Of Small GTPase Mediated Signal Transduction
Endothelial Tube Morphogenesis
Cellular Response To Hydrogen Peroxide
Cellular Response To Ionizing Radiation
Pathways
ARL13B-mediated ciliary trafficking of INPP5E
RAS processing
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Botulinum toxin type A
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Height (
18391951
)
Systemic sclerosis (
21750679
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
25 interacting genes:
ARL15
ARL16
ARL2
ARL3
CDC42
CETN3
FAM219A
GNAI1
GRK1
GRK7
HRAS
OTP
PTGIR
RAB13
RAB18
RAB8A
RAD23A
RAP1A
RAP2B
RASA1
RHEB
RHOA
RHOB
RND1
RPGR
12 interacting genes:
ARHGDIG
ARHGEF3
CIT
FNTA
MAP1A
NEDD4L
PDE6D
PGGT1B
PPP2CA
RHPN2
SMURF1
TNFAIP1
Entrez ID
5147
388
HPRD ID
04056
01321
Ensembl ID
ENSG00000156973
ENSG00000143878
Uniprot IDs
B8ZZK5
O43924
Q6IB24
P62745
PDB IDs
1KSG
1KSH
1KSJ
3T5G
3T5I
4JHP
4JV6
4JV8
4JVB
4JVF
5E80
5E8F
5F2U
5ML2
5ML3
5ML4
5ML6
5ML8
5NAL
5TAR
5TB5
5X72
5X73
5X74
5YAV
5YAW
2FV8
6HXU
6SGE
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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