PDE6D and RPGR

Data Source:
HPRD (in vitro, two hybrid)

		PDE6D	RPGR
Description		phosphodiesterase 6D	retinitis pigmentosa GTPase regulator
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum
	Molecular Function	GTPase Inhibitor Activity Protein Binding Small GTPase Binding	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Visual Perception Negative Regulation Of GTPase Activity Response To Stimulus	Intracellular Protein Transport Visual Perception Intraciliary Transport Regulation Of Catalytic Activity Response To Stimulus Cilium Assembly
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE
Entrez ID		5147	6103
HPRD ID		04056	02425
Ensembl ID		ENSG00000156973	ENSG00000156313
Uniprot IDs		B8ZZK5 O43924 Q6IB24	Q92834
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW	4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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