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CAMK2B and ZBTB32
Data Source:
BioGRID
(two hybrid)
CAMK2B
ZBTB32
Description
calcium/calmodulin dependent protein kinase II beta
zinc finger and BTB domain containing 32
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Endocytic Vesicle Membrane
Sarcoplasmic Reticulum Membrane
Neuron Projection
Synapse
Chromatin
Nucleus
Nucleoplasm
Molecular Function
Actin Binding
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Adaptation
Protein Autophosphorylation
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Synapse Structural Plasticity
Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Regulation Of Dendritic Spine Development
Positive Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Synapse Maturation
Regulation Of Cellular Response To Heat
Regulation Of Neuron Migration
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Pathways
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Fostamatinib
Diseases
GWAS
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Intracranial aneurysm (
29531279
)
Metabolic syndrome (
22399527
)
Osteoarthritis (hip) (
23989986
)
Systolic blood pressure (
30578418
)
Triglyceride levels (
32203549
)
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Interacting Genes
56 interacting genes:
ACOT7
ACTN4
AP5B1
ARSA
ATXN1
CAMK2A
CAMK2D
CAMK2G
CAMK2N2
CCM2L
CDC37
COL4A3
DUS1L
ETS1
FAM171A2
GAPDH
GRIN2A
GRIN2B
ITPKA
KRT86
KRTAP1-1
KRTAP10-11
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
MAD2L2
MED18
MEOX2
MGAT5B
MORF4L1
MORF4L2
MRPL11
MVP
PHKB
PLCB3
PNKP
POLR3C
POP5
RAP2B
RBFOX2
RBPMS
RNF4
RPL11
RXRG
SEMA4G
SMYD3
SPRYD7
THRB
TNPO2
TNPO3
TTC5
YWHAB
ZBTB32
ZMYM5
54 interacting genes:
ANKS1A
AR
ATXN1
ATXN1L
BLK
BOLL
CAMK2A
CAMK2B
CCDC102B
CDKN2D
CFAP206
DAB1
DAZAP2
E2F6
ELF2
ERVK-6
FANCC
GATA2
HNRNPF
HOXD4
KRTAP15-1
KRTAP19-5
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
MIEN1
MLX
MVP
MYO15B
OXER1
PATZ1
PITX1
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB1
RBPMS
RBPMS2
RHOXF2
SHARPIN
SPAG8
TEX37
TFAP2D
TLX3
TNPO2
TXNIP
VENTX
WWOX
ZBTB16
ZNF490
Entrez ID
816
27033
HPRD ID
12127
12055
Ensembl ID
ENSG00000058404
ENSG00000011590
Uniprot IDs
A4D2J9
B7Z1Z6
Q13554
Q9Y2Y4
PDB IDs
3BHH
3M5B
Enriched GO Terms of Interacting Partners
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