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NRAS and ARAF
Data Source:
BioGRID
(proximity labelling technology, affinity chromatography technology, two hybrid)
NRAS
ARAF
Description
NRAS proto-oncogene, GTPase
A-Raf proto-oncogene, serine/threonine kinase
Image
GO Annotations
Cellular Component
Golgi Membrane
Golgi Apparatus
Plasma Membrane
Membrane
Extracellular Exosome
Tertiary Granule Membrane
Cellular_component
Mitochondrion
Cytosol
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Positive Regulation Of Endothelial Cell Proliferation
Stimulatory C-type Lectin Receptor Signaling Pathway
Ras Protein Signal Transduction
Neutrophil Degranulation
MAPK Cascade
Activation Of MAPKK Activity
Cellular Protein Modification Process
Protein Phosphorylation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Pathways
SOS-mediated signalling
Activation of RAS in B cells
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Signalling to RAS
p38MAPK events
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
RAS signaling downstream of NF1 loss-of-function variants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Insulin receptor signalling cascade
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Estrogen-stimulated signaling through PRKCZ
RAS processing
RAS GTPase cycle mutants
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Drugs
ATP
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Oral cancer
Acute myeloid leukemia (AML)
Multiple myeloma
Adrenal carcinoma
Thyroid cancer
Hepatocellular carcinoma
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
Malignant melanoma
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Adult body size (
32376654
)
Autism (
24189344
)
Interacting Genes
48 interacting genes:
ACVR1
AKT1
ALDOB
AOPEP
ARAF
ARHGAP4
BCL2
CCDC180
CORO2A
CYLC2
DNAJB1
EEF1A1
FANCC
FBP2
FRAT2
HEMGN
HRAS
LEF1
LZTR1
MAPK3
MAPKAP1
MTOR
PIK3CA
PIK3CG
PLCE1
PPP2CB
RACGAP1
RAF1
RAP1GDS1
RASA1
RASGRP2
RASSF5
RGL2
RGL3
RIN1
RPS20
SFRP4
SHOC2
SMAD1
SMAD4
SMURF2
SRI
STX17
TDRD7
TRMO
UBE2L3
WDR76
XPA
59 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
BRAF
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
KRAS
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
Entrez ID
4893
369
HPRD ID
01273
02405
Ensembl ID
ENSG00000213281
ENSG00000078061
Uniprot IDs
P01111
Q5U091
A0A024R178
P10398
Q96II5
PDB IDs
2N9C
3CON
5UHV
6E6H
6MPP
6ULI
6ULK
6ULN
6ULR
6UON
6WGH
6ZIO
6ZIR
6ZIZ
1WXM
2MSE
Enriched GO Terms of Interacting Partners
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