RAD21 and SSU72

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RAD21	SSU72
Description		RAD21 cohesin complex component	SSU72 homolog, RNA polymerase II CTD phosphatase
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Termination Of RNA Polymerase II Transcription MRNA Polyadenylation Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Body mass index ( 26426971)
Interacting Genes		30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	4 interacting genes: MAPK8 MAPK9 RAD21 STAG2
Entrez ID		5885	29101
HPRD ID		05924	13712
Ensembl ID		ENSG00000164754	ENSG00000160075
Uniprot IDs		A0A024R9J0 O60216	Q9NP77
PDB IDs		4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE	3O2Q 3O2S 4H3H 4H3K
Enriched GO Terms of Interacting Partners?
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