SSU72 and RAD21

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		SSU72	RAD21
Description		SSU72 homolog, RNA polymerase II CTD phosphatase	RAD21 cohesin complex component
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GO Annotations	Cellular Component	Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex
	Molecular Function	Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Chromatin Binding Protein Binding
	Biological Process	Termination Of RNA Polymerase II Transcription MRNA Polyadenylation Dephosphorylation Of RNA Polymerase II C-terminal Domain	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		RNA polymerase II transcribes snRNA genes	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Menopause (age at onset) ( 29773799)
Interacting Genes		4 interacting genes: MAPK8 MAPK9 RAD21 STAG2	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		29101	5885
HPRD ID		13712	05924
Ensembl ID		ENSG00000160075	ENSG00000164754
Uniprot IDs		Q9NP77	A0A024R9J0 O60216
PDB IDs		3O2Q 3O2S 4H3H 4H3K	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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