RAD21 and CSTB

Data Source:
BioGRID (two hybrid)

		RAD21	CSTB
Description		RAD21 cohesin complex component	cystatin B
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding	Protease Binding RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Adult Locomotory Behavior Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Negative Regulation Of Proteolysis
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Neutrophil degranulation
Drugs			Cupric Chloride
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Menopause (age at onset) ( 29773799)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	8 interacting genes: CST3 CTSB CTSD CTSH CTSL ECT2 RAD21 SPRY2
Entrez ID		5885	1476
HPRD ID		05924	03091
Ensembl ID		ENSG00000164754	ENSG00000160213
Uniprot IDs		A0A024R9J0 O60216	P04080 Q76LA1
PDB IDs		4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE	1STF 2OCT 4N6V
Enriched GO Terms of Interacting Partners?
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