RAD21 and PPP1R15B

Data Source:
BioGRID (two hybrid)

		RAD21	PPP1R15B
Description		RAD21 cohesin complex component	protein phosphatase 1 regulatory subunit 15B
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Synaptonemal Complex Spindle Pole Nucleoplasm Chromosome Cytosol Cohesin Complex Membrane Nuclear Matrix Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex	Protein Phosphatase Type 1 Complex Endoplasmic Reticulum
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process Mitotic Sister Chromatid Cohesion Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Multicellular Organism Development Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Negative Regulation Of Protein Phosphorylation ER Overload Response Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)
Interacting Genes		30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80	4 interacting genes: PPP1CA PPP1CC RAD21 TRIM23
Entrez ID		5885	84919
HPRD ID		05924	17892
Ensembl ID		ENSG00000164754	ENSG00000158615
Uniprot IDs		A0A024R9J0 O60216
PDB IDs		4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE
Enriched GO Terms of Interacting Partners?
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