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POT1 and GFPT2
Data Source:
BioGRID
(two hybrid)
POT1
GFPT2
Description
protection of telomeres 1
glutamine-fructose-6-phosphate transaminase 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Shelterin Complex
Cytosol
Molecular Function
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity
Protein Binding
Carbohydrate Derivative Binding
Biological Process
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Duplex Unwinding
Positive Regulation Of Helicase Activity
Positive Regulation Of Telomerase Activity
Negative Regulation Of Telomerase Activity
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Regulation Of DNA Helicase Activity
Positive Regulation Of DNA Helicase Activity
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Fructose 6-phosphate Metabolic Process
UDP-N-acetylglucosamine Metabolic Process
UDP-N-acetylglucosamine Biosynthetic Process
Energy Reserve Metabolic Process
Protein N-linked Glycosylation
Glutamine Metabolic Process
Cellular Response To Leukemia Inhibitory Factor
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Synthesis of UDP-N-acetyl-glucosamine
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
32109421
31171785
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Fat distribution (HIV) (
21897333
)
Height (
20881960
)
Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) (
28521775
)
Interacting Genes
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
3 interacting genes:
MTNR1A
POT1
UBC
Entrez ID
25913
9945
HPRD ID
07572
04842
Ensembl ID
ENSG00000128513
ENSG00000131459
Uniprot IDs
A0A024R739
A8MTK3
Q5MJ33
Q9NUX5
A0A0S2Z4X9
B3KMR8
O94808
PDB IDs
1XJV
3KJO
3KJP
5H65
5UN7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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