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POT1 and STUB1
Data Source:
BioGRID
(two hybrid)
POT1
STUB1
Description
protection of telomeres 1
STIP1 homology and U-box containing protein 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Shelterin Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Chaperone Complex
Molecular Function
Protein Binding
Telomerase Inhibitor Activity
DEAD/H-box RNA Helicase Binding
Telomeric DNA Binding
Single-stranded Telomeric DNA Binding
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
G-rich Strand Telomeric DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
G-rich Single-stranded DNA Binding
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Telomere Maintenance Via Telomerase
Telomere Capping
Telomere Assembly
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Duplex Unwinding
Positive Regulation Of Helicase Activity
Positive Regulation Of Telomerase Activity
Negative Regulation Of Telomerase Activity
Positive Regulation Of DNA Strand Elongation
Telomeric D-loop Disassembly
Establishment Of Protein Localization To Telomere
Regulation Of DNA Helicase Activity
Positive Regulation Of DNA Helicase Activity
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Heat
ERBB2 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein Maturation
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
)
Cutaneous malignant melanoma (
26237428
)
Leukocyte telomere length (
32109421
31171785
)
Refractive error (
32231278
)
Response to selective serotonin reuptake inhibitors and depression (
27622933
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
166 interacting genes:
ACD
ACOT7
ACTB
ACTN4
ACY1
AFAP1L2
AHCY
AHNAK
AIPL1
ALDH1A1
ALDH3A1
AMPD2
ANKMY2
ANXA2
ANXA4
APPL2
ARHGDIA
ARID3B
ARRB1
BAG3
BCAS2
BIN2
C2orf74
CALD1
CAMK1D
CCDC32
CCDC9
CCM2
CFL1
CFL2
CKB
CLIC3
CNST
CORO1A
COX6A2
CPNE3
CPPED1
CRK
CRYGS
CSNK2B
CYP4F11
DBN1
DBNL
DCX
DDX19B
DNPH1
DOK2
DPP3
DPYSL3
ECI1
EEF1D
EIF3G
EIF4B
ENO2
ENSA
EPB41L1
EVL
FAM131B
FBP1
FES
GAMT
GAPDH
GAS2L1
GFPT2
GNMT
GPA33
GPR52
GRN
H2AC20
HAAO
HLCS
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA1A
IFRD2
IL1RN
ISYNA1
IVL
KHDRBS1
KIAA1191
KRT18
LAMC3
LASP1
LDHA
LDHB
MADD
MAGEA4
MAP4
MAP4K2
MAP7
MDM2
MICA
MT1X
MVK
MVP
MYO5C
NAP1L1
NCDN
NOL3
NUDC
NUDCD2
NXNL1
PACSIN1
PACSIN2
PAGE2
PAGE5
PAK4
PALM
PCP4
PDE1B
PDLIM2
PEX5
PFKP
PGLS
PGM1
PGM2
PHYHD1
PHYKPL
PIPOX
PRMT7
PROSER2
PYM1
RBKS
RECQL4
RGS14
RHOU
RIF1
RPAP1
RPSA
RTN4
SARS1
SBDS
SERTAD1
SH3BP1
SNCG
STIP1
STUB1
SULT1B1
SULT1C2
SULT4A1
SYAP1
TAGLN
TBCD
TERF1
TMSB10
TMSB4Y
TNKS
TOMM34
TPI1
TPP1
TRIM16
TRIP10
TUBB2A
TUBB4B
TWF2
WIPI2
XAGE2
YWHAE
YWHAG
ZBED2
ZBTB49
ZFP36L1
ZNF32
ZNF790
126 interacting genes:
ABL1
ACD
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BCR
BMPR1B
CASP6
CCL28
CDK4
CDKN1A
CFTR
CIP2A
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FOXP3
GHR
GPR37
GUCY1A1
GUCY1A2
HIF1A
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
INSR
JOSD1
JOSD2
KHDRBS1
LRRK1
LRRK2
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
PA2G4
PFN1
PLK1
POLB
POT1
POU5F1
PPARG
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PRMT5
PSMA3
PSMD4
PTEN
RAF1
RGS17
RHBDF2
RUNX2
RUSC1
S100A2
S100P
SIRT6
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TPD52
TRAF6
TXN2
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
VCP
XIAP
Entrez ID
25913
10273
HPRD ID
07572
06232
Ensembl ID
ENSG00000128513
ENSG00000103266
Uniprot IDs
A0A024R739
A8MTK3
Q5MJ33
Q9NUX5
Q9UNE7
PDB IDs
1XJV
3KJO
3KJP
5H65
5UN7
4KBQ
6EFK
6NSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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