MS4A7 and HMGCL

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MS4A7	HMGCL
Description		membrane spanning 4-domains A7	3-hydroxy-3-methylglutaryl-CoA lyase
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Integral Component Of Membrane	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	Protein Binding	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding
	Biological Process		Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways			Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs			3-hydroxyglutaric acid
Diseases			3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		Monocyte percentage of white cells ( 32888494)	High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		10 interacting genes: CD72 DRAM1 EMP1 HMGCL IGFBP5 ITGB2 LAT PLN PMP22 SLC35F6	9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126
Entrez ID		58475	3155
HPRD ID		07579	02003
Ensembl ID		ENSG00000166927	ENSG00000117305
Uniprot IDs		A0A024R505 A0A024R556 Q9GZW8	P35914
PDB IDs			2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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