MATK and HSPA9

Data Source:
BioGRID (pull down)

		MATK	HSPA9
Description		megakaryocyte-associated tyrosine kinase	heat shock protein family A (Hsp70) member 9
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GO Annotations	Cellular Component	Cytosol Membrane	SAM Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	RNA Binding Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway	Protein Export From Nucleus Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Cellular Response To Unfolded Protein Interleukin-12-mediated Signaling Pathway Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways		Downregulation of ERBB2 signaling	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)
Interacting Genes		24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	26 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LINC01554 LSM8 MATK MVD NELFB PTPN11 PTPRF SIRPA STUB1 SUMO2 SUMO4 SUPT6H TIMM44 TP53 XPO1 YKT6 YWHAG
Entrez ID		4145	3313
HPRD ID		02496	02770
Ensembl ID		ENSG00000007264	ENSG00000113013
Uniprot IDs		F1T0G6 P42679	A0A384P5G6 P38646
PDB IDs		1JWO 1X6G 3US4	3N8E 4KBO 6NHK 6P2U 6PMT
Enriched GO Terms of Interacting Partners?
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