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HDAC6 and AURKA
Data Source:
BioGRID
(enzymatic study, pull down)
HDAC6
AURKA
Description
histone deacetylase 6
aurora kinase A
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Cytosol
Microtubule
Microtubule Associated Complex
Caveola
Inclusion Body
Aggresome
Dynein Complex
Axon
Dendrite
Cell Leading Edge
Perikaryon
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Centrosome
Centriole
Spindle
Cytosol
Spindle Microtubule
Cilium
Microtubule Cytoskeleton
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Germinal Vesicle
Axon Hillock
Pronucleus
Perinuclear Region Of Cytoplasm
Spindle Midzone
Meiotic Spindle
Mitotic Spindle Pole
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Serine Kinase Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Protein Polyubiquitination
Protein Deacetylation
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Negative Regulation Of Microtubule Depolymerization
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Macroautophagy
Histone Deacetylation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Protein-containing Complex Disassembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Peptidyl-lysine Deacetylation
Cellular Response To Topologically Incorrect Protein
Regulation Of Gene Expression, Epigenetic
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Collateral Sprouting
Negative Regulation Of Oxidoreductase Activity
Mitochondrion Localization
Response To Misfolded Protein
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Hsp90 Deacetylation
Response To Growth Factor
Histone H3 Deacetylation
Cellular Response To Misfolded Protein
Tubulin Deacetylation
Polyamine Deacetylation
Spermidine Deacetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Signaling Receptor Activity
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spindle Organization
Mitotic Spindle Organization
Spindle Assembly Involved In Female Meiosis I
Mitotic Centrosome Separation
Response To Wounding
Anterior/posterior Axis Specification
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Anaphase-promoting Complex-dependent Catabolic Process
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Histone-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Mitotic Nuclear Division
Regulation Of Centrosome Cycle
Protein Autophosphorylation
Cell Division
Centrosome Localization
Protein Localization To Centrosome
Liver Regeneration
Positive Regulation Of Oocyte Maturation
Regulation Of Signal Transduction By P53 Class Mediator
Neuron Projection Extension
Pathways
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cilium Assembly
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA replication proteins
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA
Drugs
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Bufexamac
Phosphonothreonine
AT9283
CYC116
Alisertib
SNS-314
Cenisertib
Enzastaurin
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
AKI-001
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
2-(1H-pyrazol-3-yl)-1H-benzimidazole
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Fostamatinib
MLN8054
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
ATXN3
AURKA
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CSNK2A2
CTTN
CYLD
DYNLL2
EGFR
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H3C1
H4-16
HDAC11
HES1
HSP90AA1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LPXN
MAPK1
MAPK3
MAPT
MLH1
MSH2
NACAD
NASP
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TPPP
TRIM50
TUBA1A
TUBA1B
TUBA4A
TUBB
TUBB2A
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
VCP
VKORC1
YWHAZ
ZBTB16
ZNF205
170 interacting genes:
AATF
AKT1
ANGPTL4
ANP32B
APP
ARPC1B
ARPC2
ATRX
AUNIP
AURKAIP1
BAAT
BCL2L1
BEX2
BIRC5
BLID
BORA
BRAF
BRCA1
BTK
CBX3
CCND2
CCNE1
CDC20
CDC25B
CDH13
CDK8
CHFR
CKAP5
CORO2A
CSN2
CTCFL
CYLC2
DACH1
DKK3
EHMT2
EPHA2
EPSTI1
ERBB2
ERRFI1
FANCA
FBP2
FOXF1
FOXP1
FZR1
GADD45A
GMNN
GSK3B
GTF3C4
H3-4
H3C1
HDAC2
HDAC6
HEMGN
HIF1A
HNRNPF
HNRNPK
IFI16
IGFBP3
IKBKB
INCENP
KIF11
KIF2C
KLHL18
KLK5
LATS2
LEF1
LYPD3
MAP2K1
MAP2K3
MAP3K5
MAPK3
MAPRE2
MAPRE3
MBD3
MBP
MDM2
MED26
MTA3
MYC
MYT1
MYT1L
NANS
NAT2
NDC80
NEDD9
NF2
NFKBIA
NFXL1
NIN
NKX1-1
NME1
NSD2
NUF2
OTUB1
OTUD7B
PARP10
PAX4
PAX8
PDGFRA
PDLIM2
PLK3
PML
POU4F3
PPP1CA
PPP1CB
PPP1CC
PPP2CB
PPP3R2
PRKACA
PSEN2
PSMC3IP
PTPRD
PTTG1
PUM2
RASA1
RASSF1
RELA
REST
S100A14
SCGB3A1
SEC61B
SFRP4
SIN3B
SOX18
SOX3
SOX30
SOX4
SREBF2
SRPK1
SRPK2
SSRP1
STAT2
STK11
STX17
SUPT20H
SWT1
TACC1
TACC3
TBC1D2
TBX10
TCEAL2
TCERG1
TCF3
TEAD2
TFAP2B
TGFB1
THRSP
TLK1
TLK2
TP53
TP73
TPX2
TRMO
TRRAP
TSC1
TSTD2
UBE2C
UBE2I
UBE2N
UBTF
USP2
USP21
VHL
WIF1
XPA
YY1
ZFHX3
ZKSCAN2
ZNF189
ZNF510
Entrez ID
10013
6790
HPRD ID
02228
04066
Ensembl ID
ENSG00000094631
ENSG00000087586
Uniprot IDs
A0A024QZ26
B4DZH6
Q9BRX7
Q9NSW6
Q9UBN7
O14965
PDB IDs
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
1MQ4
1MUO
1OL5
1OL6
1OL7
2BMC
2C6D
2C6E
2DWB
2J4Z
2J50
2NP8
2W1C
2W1D
2W1E
2W1F
2W1G
2WQE
2WTV
2WTW
2X6D
2X6E
2X81
2XNE
2XNG
2XRU
3COH
3E5A
3EFW
3FDN
3H0Y
3H0Z
3H10
3HA6
3K5U
3LAU
3M11
3MYG
3NRM
3O50
3O51
3P9J
3QBN
3R21
3R22
3UNZ
3UO4
3UO5
3UO6
3UOD
3UOH
3UOJ
3UOK
3UOL
3UP2
3UP7
3VAP
3W10
3W16
3W18
3W2C
4B0G
4BN1
4BYI
4BYJ
4C3P
4C3R
4CEG
4DEA
4DEB
4DED
4DEE
4DHF
4J8M
4J8N
4JAI
4JAJ
4JBO
4JBP
4JBQ
4O0S
4O0U
4O0W
4PRJ
4UYN
4UZD
4UZH
4ZS0
4ZTQ
4ZTR
4ZTS
5AAD
5AAE
5AAF
5AAG
5DN3
5DNR
5DOS
5DPV
5DR2
5DR6
5DR9
5DRD
5DT0
5DT3
5DT4
5EW9
5G15
5G1X
5L8J
5L8K
5L8L
5LXM
5OBJ
5OBR
5ODT
5ONE
5ORL
5ORN
5ORO
5ORP
5ORR
5ORS
5ORT
5ORV
5ORW
5ORX
5ORY
5ORZ
5OS0
5OS1
5OS2
5OS3
5OS4
5OS5
5OS6
5OSD
5OSE
5OSF
5ZAN
6C2R
6C2T
6C83
6CPE
6CPF
6CPG
6GRA
6HJJ
6HJK
6I2U
6R49
6R4A
6R4B
6R4C
6R4D
6VPG
6VPH
6VPI
6VPJ
6VPL
6VPM
6XKA
6Z4Y
Enriched GO Terms of Interacting Partners
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