FANCM and EME2

Data Source:
BioGRID (pull down)

		FANCM	EME2
Description		FA complementation group M	essential meiotic structure-specific endonuclease subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleus Holliday Junction Resolvase Complex
	Molecular Function	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	DNA Binding Endonuclease Activity Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases		Fanconi anemia
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	4 interacting genes: FAAP24 FANCM MEOX2 MUS81
Entrez ID		57697	197342
HPRD ID		13876	16859
Ensembl ID		ENSG00000187790	ENSG00000197774
Uniprot IDs		Q8IYD8	A4GXA9
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?
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