FANCM and RMI1

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		FANCM	RMI1
Description		FA complementation group M	RecQ mediated genome instability 1
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GO Annotations	Cellular Component	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleoplasm Nuclear Body RecQ Family Helicase-topoisomerase III Complex
	Molecular Function	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	Nucleotide Binding Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination Reduction Of Food Intake In Response To Dietary Excess DNA Replication Response To Glucose Multicellular Organism Growth Glucose Homeostasis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Fanconi Anemia Pathway	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Fanconi anemia
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Childhood body mass index ( 33045005) Menarche (age at onset) ( 27182965 25231870) Molar-incisor hypomineralization ( 23918034) Response to statin therapy ( 20339536) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Triglycerides ( 30275531)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	5 interacting genes: FANCM HSPA13 NR1H2 PFDN1 UBE3A
Entrez ID		57697	80010
HPRD ID		13876	09867
Ensembl ID		ENSG00000187790	ENSG00000178966
Uniprot IDs		Q8IYD8	Q9H9A7
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W	3MXN 3NBH 3NBI 4CGY 4CHT 4DAY
Enriched GO Terms of Interacting Partners?
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