FANCM and RMI2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FANCM	RMI2
Description		FA complementation group M	RecQ mediated genome instability 2
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GO Annotations	Cellular Component	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	DNA Binding Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination	DNA Replication DNA Repair Regulation Of Sister Chromatid Segregation Maintenance Of RDNA Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Fanconi Anemia Pathway	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Fanconi anemia
GWAS		Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) HDL cholesterol ( 25961943) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I	2 interacting genes: FANCM NOTCH3
Entrez ID		57697	116028
HPRD ID		13876	14497
Ensembl ID		ENSG00000187790	ENSG00000175643
Uniprot IDs		Q8IYD8	Q96E14
PDB IDs		4BXO 4DAY 4DRB 4E45 4M6W	3MXN 3NBH 4DAY
Enriched GO Terms of Interacting Partners?
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