TTYH1 and HTR6

Data Source:
BioGRID (two hybrid)

		TTYH1	HTR6
Description		tweety family member 1	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Smooth Endoplasmic Reticulum Membrane Filopodium Membrane Filopodium Tip Chloride Channel Complex Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Iron Ion Transmembrane Transporter Activity Calcium Ion Binding Protein Binding Volume-sensitive Chloride Channel Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Mitotic Cell Cycle Chloride Transport Iron Ion Transport Cell-substrate Adhesion Ion Transmembrane Transport Iron Ion Transmembrane Transport Filopodium Assembly Cell-cell Adhesion Chloride Transmembrane Transport	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Idiopathic pulmonary fibrosis ( 29066090)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		5 interacting genes: CCR9 DRD2 GPR37 HTR6 TMEM60	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		57348	3362
HPRD ID		12043	03066
Ensembl ID		ENSG00000167614	ENSG00000158748
Uniprot IDs		Q9H313	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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