TRIM54 and ZBTB16

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM54	ZBTB16
Description		tripartite motif containing 54	zinc finger and BTB domain containing 16
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GO Annotations	Cellular Component	Cytoplasm Microtubule Microtubule Associated Complex Z Disc	Nucleus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organism Development Protein Ubiquitination Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Mesonephros Development Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)
GWAS		Mean corpuscular hemoglobin ( 32888494)	Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 32888494 27863252)
Interacting Genes		317 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIFM2 AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf109 C1orf216 C1orf35 C1QTNF2 C2CD6 C2orf49 C8orf74 CALM3 CARD9 CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GAS8 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1	154 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC130 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655
Entrez ID		57159	7704
HPRD ID		05928	11762
Ensembl ID		ENSG00000138100	ENSG00000109906
Uniprot IDs		Q9BYV2	A0A024R3C6 Q05516
PDB IDs		3Q1D	1BUO 1CS3
Enriched GO Terms of Interacting Partners?
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