PAK5 and ATPAF2

Data Source:
BioGRID (two hybrid)

		PAK5	ATPAF2
Description		p21 (RAC1) activated kinase 5	ATP synthase mitochondrial F1 complex assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Mitochondrion Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proton-transporting ATP Synthase Complex Assembly
Pathways		Activation of RAC1
Drugs		Fostamatinib
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	73 interacting genes: AKAP8L APP ATP5F1A ATP5F1B BEGAIN C11orf1 CDC14A CDK2AP1 CEP57 CFAP206 CRTC2 CTIF CYSRT1 DDIT3 DLGAP4 EBF1 EBF3 EIF4G1 EWSR1 FAM166B FCHSD2 FNTB GOLGA6L9 IKZF3 INCA1 KRT34 KRT40 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-2 KRTAP6-3 LGALS9B LNX1 LRRFIP2 LURAP1L LZTS2 MAGEA6 MEDAG MIF4GD NME4 PAK5 PKP4 POLR2J3 POLR3F POLR3H PPP1R16B PPP1R32 PRDM14 PRDM6 RAD54B RBM48 RCN1 REL RPH3AL RPIA SORBS2 SPATC1L SPG21 TCHP TFIP11 TP53BP2 TRIM23 TRIM27 UBAP2 VWC2 WASHC1 ZFP90 ZNF19 ZNF23 ZNF35 ZNF426 ZNF655
Entrez ID		57144	91647
HPRD ID		06423	10599
Ensembl ID		ENSG00000101349	ENSG00000171953
Uniprot IDs		B0AZM9 Q9P286	Q8N5M1
PDB IDs		2F57
Enriched GO Terms of Interacting Partners?
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