ATPAF2 and EBF1

Data Source:
BioGRID (two hybrid, two hybrid)

		ATPAF2	EBF1
Description		ATP synthase mitochondrial F1 complex assembly factor 2	EBF transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Nuclear Speck	Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Proton-transporting ATP Synthase Complex Assembly	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 28991256 25056061 29483656)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Anorexia nervosa (excluding migration to or from binge-eating disorder or bulimia nervosa) ( 28630421) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) Breast cancer ( 29059683 23535729 23535733) Carotid intima media thickness ( 26343869) Cognitive decline rate in late mild cognitive impairment ( 26252872) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 28135244 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hip circumference (psychosocial stress interaction) ( 25271088) Hypertension ( 21909115 30487518) Hypospadias ( 25108383) Inflammatory skin disease ( 25574825) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534) Platelet count ( 32888494) Post bronchodilator FEV1 ( 26634245) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30224653 28135244 27841878 28739976 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		73 interacting genes: AKAP8L APP ATP5F1A ATP5F1B BEGAIN C11orf1 CDC14A CDK2AP1 CEP57 CFAP206 CRTC2 CTIF CYSRT1 DDIT3 DLGAP4 EBF1 EBF3 EIF4G1 EWSR1 FAM166B FCHSD2 FNTB GOLGA6L9 IKZF3 INCA1 KRT34 KRT40 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-2 KRTAP6-3 LGALS9B LNX1 LRRFIP2 LURAP1L LZTS2 MAGEA6 MEDAG MIF4GD NME4 PAK5 PKP4 POLR2J3 POLR3F POLR3H PPP1R16B PPP1R32 PRDM14 PRDM6 RAD54B RBM48 RCN1 REL RPH3AL RPIA SORBS2 SPATC1L SPG21 TCHP TFIP11 TP53BP2 TRIM23 TRIM27 UBAP2 VWC2 WASHC1 ZFP90 ZNF19 ZNF23 ZNF35 ZNF426 ZNF655	9 interacting genes: ATPAF2 CREBBP ERO1A HOMEZ MTNR1B PAX5 POU6F2 ZNF423 ZNF521
Entrez ID		91647	1879
HPRD ID		10599	01256
Ensembl ID		ENSG00000171953	ENSG00000164330
Uniprot IDs		Q8N5M1	B4E2U8 Q9UH73
PDB IDs			3LYR 3MQI
Enriched GO Terms of Interacting Partners?
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