PAK5 and DNPEP

Data Source:
BioGRID (enzymatic study)

		PAK5	DNPEP
Description		p21 (RAC1) activated kinase 5	aspartyl aminopeptidase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Nucleus Cytoplasm Cytosol Blood Microparticle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Aminopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Peptide Metabolic Process
Pathways		Activation of RAC1
Drugs		Fostamatinib	Glutamic acid
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	Height ( 31562340) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	8 interacting genes: ADAMTSL4 AGT DGCR6 LNX1 MDFI MPP1 PAK5 SAT1
Entrez ID		57144	23549
HPRD ID		06423	09924
Ensembl ID		ENSG00000101349	ENSG00000123992
Uniprot IDs		B0AZM9 Q9P286	A0A024R443 B7Z7F0 E5RIA4 E7ETB3 Q9ULA0
PDB IDs		2F57	4DYO
Enriched GO Terms of Interacting Partners?
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