PCBP4 and LYST

Data Source:
BioGRID (two hybrid)

		PCBP4	LYST
Description		poly(rC) binding protein 4	lysosomal trafficking regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding	Protein Binding Protein Kinase Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus
Pathways		TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Transcriptional activation of cell cycle inhibitor p21 FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)
Interacting Genes		5 interacting genes: LYST PCBP1 QKI RBFOX1 RNF138	24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521
Entrez ID		57060	1130
HPRD ID		16343	06060
Ensembl ID		ENSG00000090097	ENSG00000143669
Uniprot IDs		A0A024R2Y0 C9J0A4 P57723	Q99698
PDB IDs
Enriched GO Terms of Interacting Partners?
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