DPYSL5 and DARS2

Data Source:
BioGRID (two hybrid)

		DPYSL5	DARS2
Description		dihydropyrimidinase like 5	aspartyl-tRNA synthetase 2, mitochondrial
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GO Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Microtubule Binding	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		CRMPs in Sema3A signaling	Mitochondrial tRNA aminoacylation
Drugs			Aspartic acid
Diseases			Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Obesity-related traits ( 23251661) Reflection (response to stress) ( 30886212) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		9 interacting genes: APPL1 CFAP161 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50
Entrez ID		56896	55157
HPRD ID		10522	07677
Ensembl ID		ENSG00000157851	ENSG00000117593
Uniprot IDs		Q9BPU6	Q6PI48 Q9H9J7
PDB IDs		4B90 4B91 4B92	4AH6
Enriched GO Terms of Interacting Partners?
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