DARS2 and ALDH18A1

Data Source:
BioGRID (two hybrid)

		DARS2	ALDH18A1
Description		aspartyl-tRNA synthetase 2, mitochondrial	aldehyde dehydrogenase 18 family member A1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	RNA Binding Glutamate 5-kinase Activity Glutamate-5-semialdehyde Dehydrogenase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Glutamate Metabolic Process Proline Biosynthetic Process Ornithine Biosynthetic Process Cellular Amino Acid Biosynthetic Process Phosphorylation Citrulline Biosynthetic Process L-proline Biosynthetic Process
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Aspartic acid	Glutamic acid
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood metabolite levels ( 24816252) Metabolite levels ( 23823483) PR interval ( 30046033 32439900) Staphylococcus aureus nasal carriage (persistent) ( 26569114)
Interacting Genes		15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	6 interacting genes: AGTRAP CDC42 CMTM5 COQ9 DARS2 SYCE1L
Entrez ID		55157	5832
HPRD ID		07677	00696
Ensembl ID		ENSG00000117593	ENSG00000059573
Uniprot IDs		Q6PI48 Q9H9J7	P54886
PDB IDs		4AH6	2H5G
Enriched GO Terms of Interacting Partners?
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