DARS2 and THSD7B

Data Source:
BioGRID (two hybrid)

		DARS2	THSD7B
Description		aspartyl-tRNA synthetase 2, mitochondrial	thrombospondin type 1 domain containing 7B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Plasma Membrane Integral Component Of Membrane
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Actin Cytoskeleton Reorganization
Pathways		Mitochondrial tRNA aminoacylation	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Aspartic acid
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Albumin-globulin ratio ( 29403010) Aluminium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Liver enzyme levels (aspartate transaminase) ( 24124411) Machado-Joseph disease (age at onset) ( 32205469) Multiple system atrophy ( 27629089) Non-albumin protein levels ( 29403010) Non-small cell lung cancer ( 23144319) Pancreatic cancer ( 20686608) Problematic alcohol use ( 32451486) Prudent dietary pattern ( 28644415) Regular attendance at a gym or sports club ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 30224653) Tooth agenesis (third molar) ( 24172245) Urinary albumin-to-creatinine ratio ( 26631737) Weight ( 28552196)
Interacting Genes		15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	25 interacting genes: AQP6 ARL13B CISD2 DARS2 FAM209A FKBP7 GJA8 GPR101 GPR152 GPR37L1 KCNJ6 KIR3DL1 LYVE1 MFSD14B MTIF3 PEX12 PIGP PLEKHO1 RANBP10 SLC14A1 SLC30A8 SPACA1 STOM SYT2 TMX2
Entrez ID		55157	80731
HPRD ID		07677	19009
Ensembl ID		ENSG00000117593	ENSG00000144229
Uniprot IDs		Q6PI48 Q9H9J7	Q9C0I4
PDB IDs		4AH6
Enriched GO Terms of Interacting Partners?
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