DARS2 and EPHA8

Data Source:
BioGRID (two hybrid)

		DARS2	EPHA8
Description		aspartyl-tRNA synthetase 2, mitochondrial	EPH receptor A8
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Mitochondrial tRNA aminoacylation	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Aspartic acid	Fostamatinib
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		55157	2046
HPRD ID		07677	01493
Ensembl ID		ENSG00000117593	ENSG00000070886
Uniprot IDs		Q6PI48 Q9H9J7	P29322
PDB IDs		4AH6	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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