PROC and NGLY1

Data Source:
BioGRID (affinity chromatography technology)

		PROC	NGLY1
Description		protein C, inactivator of coagulation factors Va and VIIIa	N-glycanase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	18 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		5624	55768
HPRD ID		01466	10118
Ensembl ID		ENSG00000115718	ENSG00000151092
Uniprot IDs		P04070	Q96IV0
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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