PROC and F8

Data Source:
HPRD (in vivo, in vitro)

		PROC	F8
Description		protein C, inactivator of coagulation factors Va and VIIIa	coagulation factor VIII
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway COPII Vesicle Coating
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma carboxylation, hypusine formation and arylsulfatase activation COPII-mediated vesicle transport Cargo concentration in the ER Defective factor IX causes thrombophilia Defective F8 accelerates dissociation of the A2 domain Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor Defective F8 binding to the cell membrane Defective cofactor function of FVIIIa variant Defective F8 secretion Defective F9 variant does not activate FX Defective F8 sulfation at Y1699
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Drotrecogin alfa Coagulation Factor IX (Recombinant) TB-402 Thrombin Protein C Human thrombin Thrombin alfa Vonicog Alfa Von Willebrand Factor Human Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol Damoctocog alfa pegol
Diseases		Inherited thrombophilia	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF
Entrez ID		5624	2157
HPRD ID		01466	02384
Ensembl ID		ENSG00000115718	ENSG00000185010
Uniprot IDs		P04070	P00451
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C	1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2
Enriched GO Terms of Interacting Partners?
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