PROC and SERPINB6

Data Source:
HPRD (in vitro)

		PROC	SERPINB6
Description		protein C, inactivator of coagulation factors Va and VIIIa	serpin family B member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Sensory Perception Of Sound Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Cellular Response To Osmotic Stress
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Drotrecogin alfa
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	7 interacting genes: F10 F2 KLK2 PLAU PLG PROC SUMO2
Entrez ID		5624	5269
HPRD ID		01466	01413
Ensembl ID		ENSG00000115718	ENSG00000124570
Uniprot IDs		P04070	A0A024QZX3 A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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