NGLY1 and TRAFD1

Data Source:
BioGRID (two hybrid, two hybrid)

		NGLY1	TRAFD1
Description		N-glycanase 1	TRAF-type zinc finger domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation	Negative Regulation Of Innate Immune Response
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 26426971 25673413) Coffee consumption ( 29367735) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC	4 interacting genes: HTT NGLY1 TRAF6 UBC
Entrez ID		55768	10906
HPRD ID		10118	10994
Ensembl ID		ENSG00000151092	ENSG00000135148
Uniprot IDs		Q96IV0	A0A024RBK4 O14545
PDB IDs		2CCQ 2CM0	2D9K
Enriched GO Terms of Interacting Partners?
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