PROC and F5

Data Source:
HPRD (in vitro)

		PROC	F5
Description		protein C, inactivator of coagulation factors Va and VIIIa	coagulation factor V
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Golgi Membrane Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Circulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases		Inherited thrombophilia	Inherited thrombophilia Factor V deficiency; Owren disease
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Activated partial thromboplastin time ( 22703881 29403010) Blood protein levels ( 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Ischemic stroke ( 26732560) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 25631615 31798171) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 25772935 32232851 28373160 31420334 22672568 31676865) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		5624	2153
HPRD ID		01466	01964
Ensembl ID		ENSG00000115718	ENSG00000198734
Uniprot IDs		P04070	P12259
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C	1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C
Enriched GO Terms of Interacting Partners?
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