PROC and CP

Data Source:
HPRD (in vitro)

		PROC	CP
Description		protein C, inactivator of coagulation factors Va and VIIIa	ceruloplasmin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen	Extracellular Region Extracellular Space Lysosomal Membrane Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Ferroxidase Activity Copper Ion Binding Oxidoreductase Activity Chaperone Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier	Copper Ion Transport Iron Ion Transport Cellular Iron Ion Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Iron Ion Homeostasis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Post-translational protein phosphorylation Iron uptake and transport
Drugs		Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human	Calcium Iron Zinc Silver Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia
GWAS		Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)	Subcutaneous adipose tissue ( 22589738)
Interacting Genes		15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1	7 interacting genes: ATP7A BTRC GAST LTF MPO PLG PROC
Entrez ID		5624	1356
HPRD ID		01466	00317
Ensembl ID		ENSG00000115718	ENSG00000047457
Uniprot IDs		P04070	A5PL27 P00450
PDB IDs		1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C	1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?
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