RNF114 and UBE2U

Data Source:
BioGRID (two hybrid)

		RNF114	UBE2U
Description		ring finger protein 114	ubiquitin conjugating enzyme E2 U
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	HULC Complex
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Spermatogenesis Cell Differentiation	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953189 25574825 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 24871463)	Severe bacterial meningitis ( 31092817)
Interacting Genes		29 interacting genes: AK5 BMI1 EVI2A MAP3K1 MAPK3 RNF38 RPSA SMURF1 TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2U UBE2W UEVLD XAF1	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		55905	148581
HPRD ID		10329	14599
Ensembl ID		ENSG00000124226	ENSG00000177414
Uniprot IDs		Q9Y508	A0A140VJY9 Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?
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