UBE2U and TRIM3

Data Source:
BioGRID (two hybrid)

		UBE2U	TRIM3
Description		ubiquitin conjugating enzyme E2 U	tripartite motif containing 3
Image			No pdb structure
GO Annotations	Cellular Component	HULC Complex	Cytoplasm Early Endosome Golgi Apparatus Dendrite
	Molecular Function	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Protein C-terminus Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Nervous System Development Protein Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Severe bacterial meningitis ( 31092817)	Malaria ( 31844061)
Interacting Genes		68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2	30 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM2 TRIM21 UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2I UBE2K UBE2U UBE2Z USP32
Entrez ID		148581	10612
HPRD ID		14599	05690
Ensembl ID		ENSG00000177414	ENSG00000110171
Uniprot IDs		A0A140VJY9 Q5VVX9	B7Z5Y8 O75382
PDB IDs		1YRV
Enriched GO Terms of Interacting Partners?
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