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UBE2U and SYVN1
Data Source:
BioGRID
(two hybrid)
UBE2U
SYVN1
Description
ubiquitin conjugating enzyme E2 U
synoviolin 1
Image
GO Annotations
Cellular Component
HULC Complex
Hrd1p Ubiquitin Ligase Complex
Hrd1p Ubiquitin Ligase ERAD-L Complex
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Protein Binding
Metal Ion Binding
Unfolded Protein Binding
Chaperone Binding
ATPase Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-specific Protease Binding
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Immature B Cell Differentiation
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Retrograde Protein Transport, ER To Cytosol
IRE1-mediated Unfolded Protein Response
ERAD Pathway
Protein Stabilization
Protein K48-linked Ubiquitination
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Endoplasmic Reticulum Mannose Trimming
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
XBP1(S) activates chaperone genes
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
Severe bacterial meningitis (
31092817
)
Blood protein levels (
28240269
)
Crohn's disease (
32581322
)
Interacting Genes
68 interacting genes:
ANAPC11
BARD1
BFAR
CADPS2
CBL
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
UBA1
VPS11
VPS41
ZSWIM2
13 interacting genes:
APP
ATN1
CLU
ERN1
GPR37
TP53
UBE2D2
UBE2D3
UBE2G1
UBE2U
UBE2Z
USP15
USP7
Entrez ID
148581
84447
HPRD ID
14599
07618
Ensembl ID
ENSG00000177414
ENSG00000162298
Uniprot IDs
A0A140VJY9
Q5VVX9
Q86TM6
PDB IDs
1YRV
6A3Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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