EXOC2 and SERGEF

Data Source:
HPRD (in vitro, two hybrid)

		EXOC2	SERGEF
Description		exocyst complex component 2	secretion regulating guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Flemming Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding Protein N-terminus Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Regulation Of Entry Of Bacterium Into Host Cell	Signal Transduction Negative Regulation Of Protein Secretion Regulation Of Catalytic Activity
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 25903422 25574825 23143594) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) WaldenstrÃ¶m macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)	Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 26426971)
Interacting Genes		9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53	8 interacting genes: DPH3 EXOC2 FOXH1 HGS KDM1A PITX1 PRMT6 SPAG8
Entrez ID		55770	26297
HPRD ID		11544	06926
Ensembl ID		ENSG00000112685	ENSG00000129158
Uniprot IDs		A0A024QZT2 Q96KP1	A8K8C1 Q9UGK8
PDB IDs
Enriched GO Terms of Interacting Partners?
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