EXOC2 and VPS53

Data Source:
BioGRID (two hybrid)

		EXOC2	VPS53
Description		exocyst complex component 2	VPS53 subunit of GARP complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Flemming Body	GARP Complex Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome EARP Complex
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding Protein N-terminus Binding	Protein Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Regulation Of Entry Of Bacterium Into Host Cell	Lysosomal Transport Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 25903422 25574825 23143594) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) WaldenstrÃ¶m macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)	Apolipoprotein A1 levels ( 32203549) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Prostate cancer ( 23535732) Triglyceride levels ( 32203549) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53	2 interacting genes: EXOC2 VPS52
Entrez ID		55770	55275
HPRD ID		11544	07720
Ensembl ID		ENSG00000112685	ENSG00000141252
Uniprot IDs		A0A024QZT2 Q96KP1	B3KS06 Q5VIR6
PDB IDs
Enriched GO Terms of Interacting Partners?
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