EXOC2 and ESX1

Data Source:
BioGRID (two hybrid)

		EXOC2	ESX1
Description		exocyst complex component 2	ESX homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytosol Plasma Membrane Membrane Flemming Body	Chromatin Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Protein Kinase Binding Small GTPase Binding Protein N-terminus Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Regulation Of Entry Of Bacterium Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 25903422 25574825 23143594) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) WaldenstrÃ¶m macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)
Interacting Genes		9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53	2 interacting genes: EXOC2 TRAP1
Entrez ID		55770	80712
HPRD ID		11544	06503
Ensembl ID		ENSG00000112685	ENSG00000123576
Uniprot IDs		A0A024QZT2 Q96KP1	Q8N693
PDB IDs
Enriched GO Terms of Interacting Partners?
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