SERGEF and SPAG8

Data Source:
BioGRID (two hybrid)

		SERGEF	SPAG8
Description		secretion regulating guanine nucleotide exchange factor	sperm associated antigen 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Molecular_function Protein Binding Microtubule Binding
	Biological Process	Signal Transduction Negative Regulation Of Protein Secretion Regulation Of Catalytic Activity	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 26426971)	Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: DPH3 EXOC2 FOXH1 HGS KDM1A PITX1 PRMT6 SPAG8	87 interacting genes: ARMC5 B9D2 BATF2 C19orf54 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581
Entrez ID		26297	26206
HPRD ID		06926	12039
Ensembl ID		ENSG00000129158	ENSG00000137098
Uniprot IDs		A8K8C1 Q9UGK8	A0A140VJV0 Q99932
PDB IDs
Enriched GO Terms of Interacting Partners?
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